My 45-70's (Marlin 1895 and Navy Arms Rolling block) gave me the 2 most memorable shots on game I've had so far.
The Marlin with a 300gr HP on a Whitetail in a snowstorm in the woods.
The Rolling block with a 405gr cast loaded with black on a mule deer on the prairie on a very cold and bitter day.
No scopes, 1 shot each, no chasing and no tracking after the fact.