Where the heck did you find speer 400grs???
Anyway, I've been plinking with a light load of imr 4198/cast bullets, my hunting load is 50gr imr 3031 with a 400gr jacketed lead. Max load according to the lyman 49th is 52gr, mine shoots well with 50gr and it's not a compressed load.
I'd have to check my records to see what I load with the hornady 350gr's, but it's out of the hornady manual a couple gr less than max again with 3031.
I never did find a good load with mine for the 300gr leads, and never had the opportunity to try the noslers.
I tried a couple different powders, but it shoots well with 3031/4198, and those are powders some of our other guns like, too, so I just stick with them.