I would pass on the Lott and the .458 as I believe a straight wall cartridge to be a mistake in a bolt gun, and while the Lott had admirable ballistics, the .458 is wimpy. I would consider either the .460 Weatherby or the .460 G&A (sort of a .458 Ultramag) if I was looking for a .45, and since I could achieve the ballistics I need with the G&A I would probably pass on the Weatherby.
At this stage though, If I wanted a heavy I would be more inclines to choose a .50, in the .500 Jeffery class than I would anything smaller or larger. I disagree with the premise that a high velocity .458 (500 @ 2700) is better on very heavy game than is a heavy big bore bullet fired at moderate velocity. High impact velocities from close range shots are prone to exhibit erratic penetration, particularly when long, heavy for caliber, solids are chosen. Unless a very fast twist barrel is chosen, the long bullet exhibits significant yaw on impact and this precession limits penetration and the ability of the bullet to penetrate in a straight line due to its leading surface now being on its side rather than its nose. I'll concede though that modern bullet design employing flat sides and flat or hemispherical noses has improved the situation over common failures of the old Kynoch solids with sloped sides and small round noses. But a .510" 580 gr with a hemispherical nose starting at 2300 fps from the muzzle has a reputation for straight line penetration on the largest game, and hunting elephants isn't a long range gig.