I like heavy for caliber bullets combined with a moderate velocity because this combination produces excellent penetration and a large wound volume. I also like to have an exit wound. The pic I posted shows the 270 and 300 gr X's sans petals. Had the petals not broken off, would these bullets have penetrated better? I don't know, but each of those bullets would of had more momentum due to their respective heavier mass. Perhaps the increased frontal area would make up for the heavier mass, the end result being penetration equal to the bullet with the broken petals, but what would not be equal would be the wound volume which would increased by 10-15% due to the larger frontal area.
The 380 gr bullet impacting hundreds of feet per second less velocity than either X bullet penetrated to the exact same depth as both deflowered X's, with a wound volume of perhaps 4 fold. The lower velocity ensured it's structural integrity, and as a result both its momentum and wound volume were maximized. Since the largest wound cavity results in death in the least amount of time, I suppose wound volume trumps through and through penetration.
According to the what the marketing folks at Barnes say, and reports from the field seem to confirm, the TSX expands very quickly once it enters fluid bearing tissue. This in itself might be the reason that you have observed less penetration with the TSX than you did with the older series of X bullet, although I've heard complaints that some of the older X bullets wouldn't expand on North American big game. I just wish they would stop making their bullet backwards.
As I have said before, Barnes adjusts the weight of their X's based on the length of the shank. All of the hollow points are the same depth within caliber regardless of bullet weight. If we want to have a full powered .375 H&H load produce a muzzle velocity of 2500 fps, we would need a bullet that weighs about 300 grs. Why does the 300 gr bullet have an expanded diameter the same as a 250 gr bullet? This means that there is no way that the 300 gr bullet can out perform a 250 gr bullet, other than for the fact that it might not loose the petals if it's impact velocity is below 2500 fps. If the depth of the hollow point extended into the shank leaving 33% of the bullet's shank solid, expansion would be larger, and the petals would be stronger because there would be more meat on them. Ergo, you would gain penetration due to increased momentum and you benefit from a larger wound volume. If you are going to doctor the TSX, I would attempt to deepen the hollow cavity, rather than reduce the bullet.