My lighter weight "walking" rifle is a 300WSM, I use it because I have confidence in it and like the rifle, for a 1 gun arsenal I would pick my 375H&H because thats my preference.
The faster cartridges will will shoot a bit flatter and buck the wind a bit better but 2 cartridges within the same "performance window" will have very similar effects after hitting the animal, to say 100fps will make a noticable difference on game is strictly an opinion, the conditions are never reproducable, until the technology is here that lets you shoot a game animal then rewind and take the same shot with a different rifle all the "noticeable effect on game" talk will be strictly opinion.
Exactly. I have seen deer drop instantly from a .250 Savage and run a fair ways after hit with a 7mm RM and .300 WM - all with similar hits. What is the reason? There are so many factors, who knows? And all of it goes back to my original point. I've shot medium and large game with bullets from 75gr to 400gr, in calibers from .257" to .416" and it is really for the most part hard to see a difference in performance. For example, I defy anyone to watch a deer standing broadside and be able to identify from it's reaction to the shot whether it was shot with a 130gr out of a .270 Win, a 160gr out of a 7mm RM, a 200gr out of a .300 WM, a 250gr out of a .338 WM etc etc.
Some people today have been brainwashed into thinking that something new is required; or that something new is better. How on earth did the experienced old timers even get by 40 years ago? Shooting moose and elk with plain old cup and core bullets out of .270's and .30-06s, and they STILL got their game. My dad shot his first moose with a .25-06 and Winchester 120gr PEP. There was no fuss or muss. I remember shooting game with a 7mm RM and 150gr Imperial PSP ammo from Army & Navy. Deer died quickly after being hit. So did moose. We chronographed that load +25 years ago. Out of a 25.5" barrel we were seeing....hold on to your hats now ladies and gentlement...just over 2700fps. The guy beside us at the range laughed and said he was doing that out of his 7mm-08. So we bought reloading gear.
The simple fact of the matter is that marksmanship and knowledge of your prey's anatomy is paramount. You could go and grab any box of plain jane 130gr .270 Win. or 180gr .30/06 ammo and fill all of your tags (of course that would not be nearly as fun for most of us!). Practice, practice, practice. My friend and I burned through almost 200 rounds each in our BG rifles just in the few months leading up to this season. And we are ramping it up for next year.