All emotions aside, and I felt a few reading some of this, I think I see where tactical870's coming from. Sounds like you're looking to keep it interesting, after 33 deer likely from the same area, and are looking for ways to keep the challenge. Been there, just different animals in different places. I read your mentoring thread, and was impressed, you gave a good few people happy and successful introductions to the sport, hunts they'll always remember.
Where we differ is I just feel that a .22 Hornet on deer is the wrong way to keep it interesting. I believe you'll make it work, I also believe that your question for people who've done it is flawed; everyone will tout a success, nobody will pipe up with all the lost animals out there from inadequate chamberings. So that's where it gets to I see it as seeking an affirmation for a previously decided notion, nobody's going to come out here and say the put a Hornet on the button, and lost the trail just before dark. Todbartell did it with the Fireball because he knew people would read his story and everyone likes that, he seems to get a particular kick out of pushing the edge.
I would just hope there was a better way for you to keep it interesting, a lot can go wrong for the deer when you cut your overkill margins that far. 1899, for sure, I never saw less than .243 advocated for Impala, but people do these things worldwide. If you asked to use a Hornet any of the areas I've hunted they would say one of two things, 1. Hell no. 2. You break it, you buy it, meaning wounding costs. Often there's even a higher charge for a wounded animal than cleanly killed, and I'm all for it, it takes their time and resources to track, and the animal suffers. I'm not hunting for meat for my family on a frontier, I'm not recoil adverse (neither is 870, it appears), and I really have no reason to investigate micro chamberings for big game as such. I'd rather foray into classics, BP, smoothbore shotguns etc. If it's a physical limitation, say if my 110lb wife couldn't tolerate any recoil (though she shoots .375 H&H well, this is hypothetical) I can see applications. For a man accustomed to real rifles, getting pretty close to stunting for me. But hey people are spear hunting these days and making a mess of it on youtube for all to see, tactical870 will do better than that I suspect with his Hornet.
Oh, and please nobody agree with antiqueguy or egg him on, read some of his posts if you feel inclined to.