A few years ago I shot a good sized Muley buck. It was walking up a steep slope, and I was across the deep coulee, and a bit behind it. My .280 was shooting 140gr Sierras at over 3000 fps. The buck never took a step, collapsed, and then rolled all the way to the bottom of the very deep ravine-like coulee.
Over the years I've shot a bunch of deer. This season it was 5, same as it was last season. If I do my part right I expect them to fall dead right there... Maybe within 5 steps. This year I shot across a small coulee at a WT buck that had no clue I was there. It was a perfect double lung shot, but it was on the higher side of the lungs. 7WSM shooting 150 gr fusion bullets at 3200 fps [chronied]. It collapsed like lightning hit it, but when I got up to it, it was still able to move its head. It was struggling, but couldn't move from the neck down. I finished it with my knife. I thought I must have hit it in the spine, from the way it was acting, but the autopsy revealed there was no direct hit to the spine. Must've been some sort of hydrostatic shock or something that disrupted the CNS.
Most of my hits have been either right in the boiler room, and they don't run, they maybe take a couple steps at most. Or in the neck or spine, in which case they aren't going anywhere, except maybe roll down a hill. Or I didn't lead a running shot far enough, and I take out the back hip [yes, it's happened a couple times]. Still, they can't go far when that happens.