I shot a whitetail with my .223 and 70 Grn VLDs at ~80 yards. Shot through the back of the onside shoulder, bullet entered, and penetrated the shoulder/ribcage before expanding violently. Lungs were severely damaged, and then the bullet hit the offside shoulder blade, shattering it. The amount of damage was severe, and I wouldnt hesitate to do it again.
Having seen the bullets performance, I think you will have no issues shooting coyotes with it. I think that you arent as likely to see a "bang flop" as you are with some more explosive bullets, but I have no doubt you will get reasonable expansion and a humane kill.