I like first hand responses when I post a thread, so here's mine to you.
I have seen a lot of moose, caribou and Buffalo shot.
I saw a Buffalo shot in the head with a 30 06 at 100 yrds and get up and run, I saw one get up and walk away at less than 100 yrds.
I have shot 3 in my life. am not a fan of all the Mag calibres but will say that there was no walking away from a 300 wsm. Each one I shot was with my buddies 300 wsm. Bang, done! He has done the same 3 times. Our other hunting buddy, a fine shot with his 30 06, watched the Buffalo rise like Zombies even after a shot to the head.
Can a 30 06 do it. i'm sure some people can with it, but i have never seen it and would never try it. I have seen a Buffalo dropped at 150 with a 223, again, would never try it,