Had a coyote run in on me last spring close enough I busted a custom box call over his nose and once he took a couple leaps and I got the gun out of my lap two loads of #6 did the job quite well on a 60 lb male. First one killed him, second one was cause he pissed me off and screwed my morning. Any #4 hunting load will put a world of hurt on any coyote within 25yds