Its pretty hard not to like the .375 bore size or the .375 H&H ballistics. I don't mind the the .375 Ruger after shooting my pal's Ruger Alaskan. I load his ammo, and he prefers 260 gr ABs and wants them loaded a bit below maximum, so we haven't run in to the sticky brass situation with Hornady brass. When I decided I would go with the .375 Ultra, after considering then rejecting the .378 Weatherby due to the cost of brass, it was to get .375 H&H long barrel ballistics from a 20" barrel, which I did with a bit of room to spare. A 300 gr XLC skipped along happily at 2600, but where the Ultra really shines is with 380 gr bullets, where even with its short barrel, it bested the H&H by 150 fps when shooting both across the same chronograph at the same time.
I'll have a new .375 to play with this summer, but rather than another big case fire snortin dragon, this one is a .375 Scovile, sometimes incorrectly referred to as a .375-06, but in reality is a 9.3X62 opened up slightly to .375. The chamber reamer is kinda cool, allowing for the .30/06 case head size, but with the head to shoulder length of the 9.3X62. Actually this rifle was supposed to be a 9.3X62, but Ron Smith apparently doesn't make a .366 barrel, but he does make a .375, and the one I had on my Ultra shot like a varmint rifle, so the math was simple. I expect a 270 gr TSX will run about 2500 fps, which is what I got with a 270 gr bullet in the .366 Wagner, which should prove more than adequate for bear repellent, either here or in the Yukon.