I'll share my experience...
I've been shooting the .270 Win cartridge since 1989.
I currently shoot 150 grain NP's, in factory Federal Premium ammo. I bought a good qty of this ammo to prepare for, then go on a BC mule deer hunt, which never happened. I had planned on shooting out to 250 yards, and understood that a muley could weigh as much as 100 pounds more, live weight, than a NS whitetail.
I am now disabled, and hunt from a ground blind, with 70 to 80 yards being my maximum shot distance. Of all the different projectiles I have shot, out of a .270, this NP is the most shocking, literally. The front end does a giant amount of damage, and usually is in pieces, in the deer, while the back end does exactly what it's supposed to do. Some lost venison, but I never have to follow a blood trail, which suits me just fine, based on my mobility. Sure, I could get by with Federal Blue Box ammo, but my current setup shoots nice tight groups, with the FP NP 150's.
It will help us all, if you tell us your intended projectile weight, maximum hunting shot distance, and animal(s) being sought.
BF
(PS-I believe that my setup is suitable for elk, out to 300 yards, and moose, out to 200 yards, where the front end won't fragment as badly. I'll never get to try it, though, so I'll be following this thread, closely.)