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For urban warfare you bring LVLIII+ Armor, a carbine with holosights, a QD suppressor, lots of full magazines and many grenades. Oh and friends, lots and lots of friends kitted out in a similar fashion.
For self defense a good 1911 frame where the predators are bipedal, yes. I also agree with you about a bigger gun for the four legged predators too. But I would go with ~ 4"bbl.
Out of my stable, my first choice for me would be my Sig 220 followed by a Para 1911 then a Glock 21. I can shoot the Sig as well as my 1911 but I chose the Sig because of its slightly shorter barrel, lighter weight and it's a little easier/faster to field strip than a 1911. The Glock would have been on the list but I find the grip a little too slippery and a Hogue/Pachmayr wrap makes it a tad too large.