For me, the ergonomics feel the best on the Ruger MKIII 22/45. So, I bought one a while back and have been very happy with the purchase. It eats any .22 ammo I feed it with no problems and is as accurate as I could hope for(More accurate than I am capable of shooting).
But, relative to my other hand guns, it's a tough toy to clean thoroughly. And, it seems to need cleaning more regularly than my center fire hand guns(I've always thought .22's are a filthy cartridge as they always seem to leave a lot of grit behind). When my 22/45 is dirty, you can feel all the grit crunching as you cycle the action(That's also true of my semi auto .22 rifles, too).
I can't comment on how easy or tough it is to clean up a Buckmark as I've never had to clean any of the ones I played with.