I carried a S&W M&P 40 for work and the grip is very comfortable however I own a Glock 21, in fact this is my second Glock 21, my first was a Gen 2. My only beef with the S&W is the trigger is a little vague which is an easy fix with the Apex kit but the trick is finding one for the .45. The only mistake you will make is picking one based on someone else's opinion, hold them both, see how they point I'm your hand, they are like shoes, just because it fits one person doesn't mean they will fit you. Both are excellent pistols.