imbane, have you looked at/considered the Taurus 24/7 Pro?
I've heard very good things about this gun, but do not know anyone who own's one, let alone handled one.
24/7 is a great pistol for anyone/anywhere except anyone in Canada. I'm not kidding. There is ZERO customer service/repair for these pistols here. You buy it, you screw yourself.
In regards to the Glock 21. I have it and I love it. Mine is Olive Drab. I don't actually prefer it over the M&P45 comfort wise but it shoots SO nice for a .45 polymer pistol and it really feels like a substantial mans-man gun in your hand. Also, it has the incredible reliability of a Glock pistol, it's actually kind of cool to own a gun that casually remarks to other pistols "f**k off, please." None of my other guns or other guns I've fondled/shot ever did that. I don't what it is, the gun just has it's own personality. For f**k sakes, even people who have never shot the gun or know little about firearms are drawn to it when I show off my collection or go shooting.
For posterity, here is a very nice little pic of my G22 with my G21.
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