My current favorite big animal bullet is the Swift A-Frame, but I've killed a pile of game with Hornadys, Sierras, and several dozens with the TSX. I may have drank some of the TSX Koolaid, but never deluded myself into believeing it was champagne.
The hardest of premium bullets may be the best for the hardest of premium animals, but ordinary use on ordinary animals, with ordinary cartridges may be better served with ordinary bullets.