Pro's
-Adjustable LOP, fit different positions or amount of clothing or the whole family with one gun. Now that I have this adjustability I won't give it up.
-Take down ability, a drop of loctite on the castle nut and you can spin the butt stock on and off to same position for take down on long pack in/outs. This is the poor mans ultralight takedown option.

-Accuracy
Con's
-Most are heavy, but you can build hunter friendly rigs.
-Cold, there are rubber inserts that can help on front end and rubber/poly grips and some $ carbon rigs out there.
-Non-traditional sling carry, you want side sling so they lay flat on back to keep pistol grips and extended magazines from jabbing you.
It's a 'get used to a different platform' sort of thing.
You get a lot more versatility in set ups from butt stock choices, grip choices and other accessories you can add for variety of reasons, think modular. you can sure pile on the weight in a hurry but with careful selection you can get em pretty trim as well. Lots of alpha mountain studs running builds on the XLR carbon stuff with carbon barrels etc.
The Howa pictured in in 6.5 Grendel is a good way to go light. I had a 20" lightweight in a gen 1 mdt Lss and my machinist took 7 oz of fat out of that get 1 chassis. The howa with Talleys and Leupold 3.5-10x40 was 6 lb 10 oz all up, one of the lightest chassis builds I've yet seen and could have topped it with my fixed Leupold 6x36 and had it right at 6.5 lbs all up, it wore a MFT battle link minimalist butt stock and ergo slim grip.
I've since migrated to Ruger American Ranch in MDT LSS-XL Gen2 and current build is 8 lb 2 oz scoped in Talleys and Trijicon 3-9x40 Accupoint, magpul ctr butt stock and moe-k grip. My machinist was only able to get 3 oz out of that chassis so MDT has definitely figured out how to cut fat but love the XL length for laying prone over packs or bipod/shooting stick work...I found the regular LSS chassis too short for my tastes in these regards.
Once you adapt to the 'AR' modularity and carry options you get quite pleased with it all. We've been spring bear hunting now and so far most of November for deer/moose and the chassis is doing good. We did another season of deer and coyotes as well and my oldest dumped a whitetail at 238 and I took a coyote at 200 and was quite surprised how good that chassis system felt on that coyote, a lot of control and solid on the stick. My youngest dumped a bear at 10 yards and a nice whitetail over the pack at 300, I'll use the same gun for the other kid and myself also, adjusting the LOP is fantastic. The mag release button stuck out too far for my tastes on my AR magazine model but easy fix just taking 1/8" off the screw the button threads into and it allowed me to countersink the button into the side of the chassis rather than stick out. Little things that are hunter friendly seem easy enough to fix. Ergo m-lok rail covers are fantastic rubber inserts to warm up and or quiet/dampen the front end, lots of rubber or warmer poly grip options as well to match...it's just that central one hand magazine area carry where you'll want a glove. Not looking back now that I've made the move and been playing with these for a few years now on several platforms, we only hunt. Predators and big game combined.