This is for more serious shooters looking to improve on their results. It's worth keeping in mind that with a good rifle/barrel and good shooting skills, there are several reasons why rounds don't go "where they should".
First, as horseman2 says, is wind. At 100 yards, every 1 mph change in crosswind between shots will move a .22LR bullet about 0.36". When winds are switchy, changing directions and velocity unpredictably, it's very difficult to get repeatable accuracy performance.
Unless the shooter can accurately account for wind changes, which requires a number of wind flags, 100 yard shooters are best advised to shoot in the calmest wind conditions possible.
Second, is ammo MV variation. At 100 yards, each 10 fps difference in MV between rounds results in about 0.25" of vertical dispersion. When you consider that a box of good match ammo can be expected to have an extreme spread of 30 - 35 fps, it's possible to have 0.75" of vertical dispersion just from MV variation. Many lots of match ammos will have an ES of 40 and more fps. When using entry level match ammos such as SK varieties or the less expensive Eley or RWS varieties (not to mention CCI SV or other SV ammos), ES is often much higher with comensurate vertical spread.
Test different ammos to find the lots that produce the least vertical.
Third, is the bullet itself. Imperfect bullets cause unanticipated changes in POI. Two main problems occur with soft lead .22LR bullets. One is the bullet heel. If this isn't perfect, if the heel is uneven or otherwise improperly formed, the bullet's trajectory will be affected. In other words, it won't fly true.
The second is the bullet's center of gravity. Unlike jacketed centerfire bullets, soft lead projectiles like .22LR bullets and airgun pellets, can't be consistently made in quantity without having an offset center of gravity. Cg offset can vary by lot, from box-to-box, or from round-to-round within a box. When Cg is offset, bullet dispersion is affected. Some lots of the same variety of ammo will shoot better at distance than others. Cg offset is also affected by the rifle's bore. The chamber/leade and bore will obturate or deform each round in a particular way.
Unfortunately, it's not possible to identify center of gravity variation. The only way to know if one lot of a match ammo, say Center X for example, will have more or less dispersion at 100 than another lot of Center X, is to test it by shooting.
The bottom line is to test for the best ammo and to shoot in calm conditions unless you are able to accurately account for wind changes. Either way, flags are needed. Even when it's calm, flags are needed to confirm that there is minimal air movement. It's nearly impossible to see slight changes in air movement without flags. Slight changes in air movement can affect a .22LR bullet trajectory.