My technique brushes on many of the points already made, but also diverges from them. Speaking in generalities, and not to the specifics of the equipment in question this is how I go about it. Just for the same of the discussion I’ll use a bead front which for me, my rifles, and the barrel lengths I usually use seems to regularly cover 8” at 100 yards. Your’s can vary, but knowing what it is will come into play in a bit. I’ll sight it so the POI is at the top of the bead at 100. This allows a precise aiming point from zero to out past 100, how far depending mostly on velocity because BC doesn’t enter into it much at powder-burn ranges like that.
Still with me? On a big game sized target, if you think about it wouldn’t have mattered much if you had aimed with the center of your bead, you’d still have your deer it you did everything else right. Much past the 100 mark, depending on trajectory the POI starts dropping behind the bead, but remember its still behind the bead. Everything behind the bead is still in a whole lot of trouble for good long ways, and although the top of the bead doesn’t change the apparent size of the whole bead is getting bigger. It doesn’t track exactly, doesn’t have to but the ITBTB ( In trouble behind the bead, technical term I just made up

) does stretch with range, at least its going the right way.
How far this will work depends on the apparent size of your bead to you and your trajectory. In really broad terms though, even rather anemic cartridges will keep you in vension out to as far as you can keep the bead on a deer’s body, which is already at or past the point of thinking about quitting. Darn front sight turned into a range-finder.