Thanks, I understand all of that, and actually had checked out the site you linked. I also understand that using this rifle/cartridge combo limits me somewhat. However, I'm kind of stuck with a stupid fascination for "old timey" rifles, so the 1873 is what I'm using.
I'm definitely not the most experienced hand loader, I started out pressing ammo for my .45 Colt Vaquero using 250 gr cast and Trailboss (because of its reputation for being relatively idiot-proof). I typically go overboard when setting up for something, so I've got pails and pails of the stuff.
Given that fact, I'd like to use what I've got. The problem is, I'm having a hard time finding actual consumer results with this particular combination of powder/bullet/rifle/application.
I guess my original post wasn't worded properly, what I'd like to know is this: does anyone here have some experience using an 1873 replica (in .45) for medium-big game hunting? And what ammo recipe did you successfully brew up?