That's reason enough.
I did it with several 375s over the years. In the end, I found myself enjoying the smaller girly gun chamberings at the range and sold the med. bores all off.
The largest I have now is a 300H&H and no magnums otherwise. I may sell that and go to the 280 or another 30-06 for larger stuff with heavy NPs.
I'll probably do the same when I start becoming frail...
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