Never made any claims of being perfect. I've completely missed 3 shots this year, and took 43 squirrels. Missed entirely. As in the squirrels ducked/moved at the instant of the shot and my pellets passed clear, with no injury. I have also missed one partially, only knocking it out. Had to take a follow-up shot a few seconds later, which finished the job. The squirrel was unconscious but alive between those two shots, as I mis-estimated the range slightly and hit a bit high, damaging the upper part of the brain with a pass-through.
As I said, I try to avoid shots where there is doubt. As a result I don't take a lot more shots than I do. As you say, hunting is not target shooting. There will always be compromises involved, but one ought to strive to make these minimal by working on the related skills. If I find myself distracted in some way, whether it's excitement causing a lack of steadiness or some other factor, I put the gun down and focus on my breathing. It seems too few hunters give much importance to precision bullet placement, going by videos like the second one early in this thread - those half dozen or so shots from a Glock made me feel only disgust with the shooter and pity for the animal which had to suffer such a drawn-out death to satisfy that idiot's ego. Even more amazingly, he shared the video, and not out of a need for atonement. He was actually pleased with himself!
Obviously, ricochets are undesirable to say the least. I've read a number of accounts here on CGN, and more elsewhere, of even fairly substantial bullets being found in deer and other game by hunters as they butcher the animals. Not the bullets which made the kill, but bullets the wounds from which the animals had survived and even healed, often with broken ribs or legs involved. If someone's only capable of hitting a paper plate at 100, the edge of that plate puts the bullet up to 5" away from the proper bullseye, which is to say between spine and shoulder if high and rearward, or between ribs or hitting the sternum if low. Shattering a foreleg perhaps but without a clean kill. It doesn't seem like much of an argument in this context. Nobody is perfect. Not even close. But not even trying for a high level of skill in something like hunting where the suffering of another living being is on the line sounds immoral.
Your analogy of squirrel hunting to deer hunting is terribly faulty and you have drawn improper conclusions. I have hunted both deer and squirrels for more than four decades. On squirrels I ONLY take head shots, on deer I NEVER take head shots. Squirrels hit poorly or well but not incapacitated can get themselves into an unrecoverable position before expiring. In addition squirrels have a fragile skeletal structure and the ratio of lead bullet to body mass is significantly higher in the ".22 LR vs squirrel" as opposed to the "180-200 grain vs deer." A fatally wounded deer shot through the lungs (a 10" target) cannot (generally) get to an unrecoverable position and will leave a substantial blood trail. Where as the "attempted" headshot on deer is fraught with opportunities to fail... having outfitted and guided for many years, I have seen more than my share of attempted headshots, and have tracked and not recovered WAY too many of them, bullets through jaws, neck tissue, glancing blows off skulls etc... also, watch deer and watch the quick movements they make with their heads, your actual lethal target is 2 1/2," outside of which you are likely to badly injure but NOT recover the animal... it is true that on a really bad shot you may miss entirely (best case scenario), but considering you are attempting to hit the smallest target to create a fatal outcome, a really bad miss is a ten fold failure, and a slightly bad miss is a disaster.
Headshots on big game animals are just too risky and to my thinking and in my practice should not be promoted.