Kool, schmool. As a firm believer in tolerance and diversity, I have never met a cartridge that I did not like.
Let's get back to basics; we're descended from apes. Apes throw things. The first proto-gun nut was probably an ape who brained a leopard or its dinner with a well-aimed rock. All other projectile weapon developments since have been refinements on that first rock, from sharpening the rocks and putting better handles on them to small, light, high-penetration/high velocity rocks launched from bows to metal rocks, and finally to launching rocks out of tubes with gunpowder.
Give that first rockthrowing ape a badly maintained, bubba'd Remmy 710 in .30-06 plastered with Hello Kitty and Liberal Party stickers, and his reaction would be "Ook? Ook?! OOOK! OOOOOOK! OOOOOOK!" Which, roughly translated, means "That critter way over there? I can kill it from here with this? And it makes a really loud bang? KOOOL!"
His next reaction would probably be to look at a cartridge, scratch his head, and say "Gronk, oook oook oook?". Which means "Hey, is there any way we could squeeze some more gunpowder into this thing?"
Anything that lets fat, out of shape, middle-aged human beings like me go out into the wild (or even my back forty) and kill dinner like their ancestors did? That's cool in my books, and I wouldn't turn down a gun in any of those calibers, assuming it was in good shape and shot well. Hell, that first rock would be really cool to have, too.