I use a 222 or switch over to a 22-250 when yotes start to hold up at 300 plus. Hunting partner went to a 20 tactical...basically a 204... I have to say the 20 calibres kill like nothing I have ever seen. 22-250's, 243,etc shoot through them and many times they run or spin and yulp for a few seconds. With the 20's the yotes just pile up and twitch a bit.
Try using 52gr Speer HP Varminters in your 22-250 they do not shoot thru.


















































