I like em all, even the .243, which I bad mouth as frequently as possible. I don't know what Warren Page was thinking! Actually its a good cartridge when used within its limitations; I've killed a number of butterflies with mine.
There are many really good cartridges out there, but I think the top 3 are the .270, the .280, and the .30/06. For me the '06 wins out because it shoot as flat, as far, and as tight, as I can shoot any rifle under field conditions. While the .270 and the .280 do likewise, there are much heavier .30 caliber bullets available than there are .270 or 7mm. The ole girl nudges the powerful rifle category when loaded with 220 and 240 gr bullets, and yet it has a mild disposition when compared to the fire breathers that fling those same bullets at 3000 fps, without giving up much close range terminal performance. Loaded with light bullets its deadly on varmint sized targets, although it can be a bit hard on pelts unless you load cast bullets, or FMJs, which also makes it a wonderful small game cartridge. With 130 gr TTSXs, or 150 gr traditional bullets, it shoots flat and has the ideal terminal performance for deer sized game. Loaded with a good 180 gr bullet, it has taken every species of North American big game, and shines on moose and bear. My primary .30/06 is a classic, a Brno ZG-47. My .270 is a classic too, a M-54 Winchester, but it just never grabbed my imagination the way the .30/06 did. According to Clint, it will even keeps interlopers off the lawn.