I love the look of a Ruger #1, and especially enjoy the mechanical sound and feel of dropping the block, inserting the cartridge, and then raising the lever and snapping it shut. I always thought that #1's were the classiest regular production rifle available for purchase by the average working man...but their prices have absolutely skyrocketed in recent years, so they're no longer the terrific value they once were. The 1885 is a distant second.
The H&R singles were a favourite, always shot and functioned well for me. I had a couple of Buffalo Classics and still can't figure out why I didn't keep one. Mine shot 90% as well as my C.Sharps 1875, for only about 20% of the price. But the eyes aren't what they used to be, so this type of gun is just a toy for me now, no serious iron-sight hunting anymore.
Played with Contenders and Encores for a bunch of years, always liked the way they shot, never cared for their 2x4 handling qualities...and, man, ugly with a capital ugh!
I circled around getting a Blaser K95 for awhile, almost bought one a couple times...and then stumbled upon the gun that is now the apple of my single-shot eye. It's a Haenel Jaeger model 9, a sort of poor-man's K95. Same tilting-block action, terrific set trigger, de-cocking safety, weighs nothing, aiming is like pointing your finger. The QD scope mount system is just as good as the Blaser one...which is to say, it is perfect. No discernible change in POI after multiple disassembly/reassembly cycles.
I got mine from Wolverine; sadly, it looks like they are no longer importing them. A shame, because they are delightful little guns.