The MEs out at 400, 500, 600 yards of the 375 Ruger factory ammo is greater than most conventional big game hunting calibers at the muzzle.
If you know the trajectory of your 375 Ruger ammo fired from your gun and have the skill to place the bullet correctly this is the mother of all long range timber clear cut hunting guns.
That 270 grain SP reaches out a long, long way to anchor that moose to the ground.
My brother-in-law has a Mark V in 378 Weatherby (a suped up 375) and likes doing that Quigley kind of hunting from tree stands on the edges of clear cuts.
He's deadly with that gun.
His motto is "let the bullet do the walking".