I have killed coyotes with most varmint cartridges with heavy and light bullets. For me, a small case pushing a light bullet as fast as possible is the best up-to 400 yard medicine. A 22/250’s extra horsepower isn’t needed imo. The 222 RM is a small step over the 223 which itself is hard to argue against as the most efficient, cheapest and easiest way to do it. Most heavy 22 cal bullets are made for paper or bigger game anyways. Having a fast twist gives you added flexibility but for a pure varmint gun, isn’t needed.