I'd carry a one of my .22s for ruffies and other birds while useing a rifle for big game. I suspect I'd at least pop a few deer for novelties sake, since I have them anyway.
Houndsmen would find a use for treed animals. Handgunners would welcome a chance to use their weapon of choice.
Some will hunt with the handgun for its higher difficulty level, and others will do it because they want to and just offer the difficulty thing as a reason.Nothing wrong with that.
There's bit of paradox to the difficulty thing anyway; there's 1000 ways to make hunting harder and less effective but guys are pretty selective about the "difficulty factor" they want. Hunting in piss poor areas, or barefoot, or in a Santa Claus suit in the desert would certainly be difficult but lack any popularity at all. On the otherhand, hunting deer in concentrated areas with a string gun over an oat pile might make the hunter feel like one of the elite while remaining about as hard as kicking yote#### down the road. Nothing wrong with that either.