The best thing you can do (and hopefully you are located close to a gun store with a lot of .22s in stock) is to actually go into the store and handle a few. Pictures, product specs, pricing and internet opinions are great and all, but nothing compares to having them all in front of you, or in your hands to compare. Once you find the one that feels right to you, take it home.
I bought the 10/22 in the end, but it's a scoped rifle. There's something about the shape of the stock that makes it damn near impossible for me to use the factory sights. Other rifles are much easier for me to do so for some reason. The 10/22 is a rather short-feeling rifle. Others (and I believe it was the 597 mentioned before) have a better 'real rifle' feel to them in terms of proportions. I love the rotary magazine of the Ruger. It's a great design, and feeding issues were very minimal when the rifle was stock, and now non-existant with the VQ extractor installed. I also use the steel-lips 25 rounders, but they tend to be a touch more problematic (one magazine I have tends to freeze, while the other works flawlessly for the most part).
Who'dve thought that I'd end up with a Ruger 10/22 when I walked in the store. When I pushed open the door, I was all set on a Marlin model 60. Funny how handling my options and having them in front of me changed my mind very quickly. I'm sure it is a good gun as well, but it just wasn't for me all things considered for my purposes.