My cz 375 works fine on deer.It does not drop them any faster than my 30-06 however.Meat damage has been minimal.I use the 260 grain accubond.The rifle is heavy,but I shoot heavier rifles much better offhand than lightweights.With my 375 I load it with 14 grains of unique behind a 200 grain lead bullet for practice.Fun shooting gongs at 200 meters with that load.Very cheap to shoot for practice rounds.The first time I ever shot a 375 I had to have one of my own.I mostly have it for bear and moose now and carry a 25-06 for deer,but it is by far my favourite cartridge.Not one I will ever regret buying.