6.5s are popular because they don't recoil much and there are a gigahillion bullets available in that diameter, many being heavy for caliber. The caliber doesn't make it effective, nor does the SD because SD doesn't factor in bullet construction. A 180gr 30 caliber Partition will lodge under the hide of a moose at 300 yards when launched from a 300 Winchester and has a lower SD than the 6.5 140gr. I'm doubtful that you'd get similar performance out of even a fast 6.5 at half that distance. There's a venn diagram of speed, SD, and construction that needs to be balanced.
Yup a wildly subjective mess. The partition was a great 20th century answer ensuring enough retained SD to penetrate deeply for our bigger game animals. The head stamp means nothing. If you use the same SD partition from a 6.5 and impact at same velocity, it too will be under the hide of that moose at 300 yards. You'd likely burn half the powder to do it though which is more beneficial to you and make it more likely to shoot well for a variety of shooters than the 30 cal option and the moose still dies. To run same SD to a 140gr 6.5 bullet in .30 cal you need to throw 190 gr bullets, not fun for many to shoot well.
It should also go without saying that making the comparisons you'd also compare similar construction types to assume similar SD reduction rate and therefore penetration. Silly to compare a delayed controlled expansion bullet against a rapid controlled expansion bullet. But you can vary things along the scale as you say. As in my preferred formula is higher than adequate SD in rapid controlled expansion bullets and moderate to low velocities...as they are nice and long and behave more like the 20th century answer partition as the front end of bullet gets to open up nicely and do lots of work internally for the shorter recoveries we all love but there's plenty of bullet left on the tail end to ensure adequate penetration. So you can skin the cat as many ways as you like once you have the mental visuals of how all this works. You can be smarter about how much powder you burn to get the sort of bullet performance you enjoy and prefer. The 20th century answer (one of the best answers) was to throw a 180 out of a 30 cal pretty hard and a partition was a top choice but not a top choice for a good bunch of the shooters in terms of shoot ability and hit probability. You can equal that formula now with less than half the recoil of that old combo.
It's hard to give up the institutionalized head stamps and displacements etc. but the right numbers and choices tell the story, we have a far better understanding of terminal ballistics than we did in the 20th. We still have a ways to go to equal our in flight ballistics understandings but we're well on our way now to catching up to that on the terminal end. There are many people on rokslide killing big game including elk to 400 yards with .223's and 77gr tmk's for years now and documents on rokslide forum, they are taking terminal ballistics know how and knowledge to the top of food chain and if you showed up there with the ole throw a 180 out of a 30 argument you'd instantly end up so far behind you'd think you were first. Still wildly subjective but there's lots of ways to get 24" of penetration range over a broad impact velocity spectrum with now than we had before, we no longer need to be pounded with 20+ ft/lbs of recoil energy to do it. Mr. Bell paved the way.