I for one like the "one big game rifle" concept. You still need other guns for other duties, but to me the one rifle for all big game is sensible. I also have taken to the sawed off Brno 602 .375. Trajectory is flat, and things are brought to a conclusion in short order.
The one rifle concept however must take into account the virtues of several rifles. It must be "friendly" to the shooter which will encourage him to have it as his regular companion. It must be pleasing to his eye, and possess the feel that becomes part of the individuals subconscious. It must be short, light and quick to bring into action so that it is equally at home on the prairie or in dense bush. It must function with absolutely dependability. It must have a flat trajectory out to what is considered long range for a big game. Yet it must be able to fire a bullet into a large dense animal at bad breath range without the danger of bullet blow-up ever coming into question. It must be cheap enough to shoot to encourage regular practice, and accurate enough that it instills pride and confidence.
I am fortunate enough to have all of these qualities in one rifle. I can carry this rifle for any big game scenario on the planet (provided I can get it there). All that is required as I go out the door is the correct choice of bullet and the correct sight. The 300 gr TSX almost makes bullet choice a foolish question. I can hit well out to a quarter mile with the scout scope, although a Dall Sheep hunt might cause me to consider mounting my 1.75-6X.