I'd stick with something between a 22-250 at the low end and a 7-08 on the high end, especially since you're considering wolves. Not to say the 22-250 doesn't have what it takes, but if you make a marginal shot, the bigger bullets of the calibers mentioned by Hoytcanon and others might be able to save you some tracking distance by hitting with a little more energy. I currently use a 22-250, but would like to add a 243 or 25-06 to the arsenal.