Finding the BC of every bullet will tell you how much of any POI changes you see might be due to bullet imperfections. Finding the BC of every bullet literally tells you whether the bullet was in good shape, average shape, or beat up. And finding the BC for a whole bunch of them tells you how good or bad any manufacturer is at keeping bullets in good shape. I don't know why you say it is invariably because of bullet imperfections. There's more than one reason for it happening, and that statement of yours literally means that is the only reason, which is not correct. I don't think your words were chosen carefully there. But finding the BC of every bullet will tell you how much of a difference you should've seen on target because of it, and the target itself will tell you whether or not there was that much difference. And when the two don't align, that tells you there are also other variables at play, which I've already tried to illustrate.
You say you don't know why I said that bullet imperfections are key to understanding why MV and POI mismatch may occur. I'll attempt to explain again for readers in general.
Among well formed .22LR match bullets, the key imperfection remains center of gravity variation between bullets and lots of bullets. This has little if anything to do with variation in weight between bullets.
I didn't "invent" the idea of bullet imperfection in the form of center of gravity issues. Despite how new or unfamiliar it may appear to any readers here, rest assured that it's an established idea. For example, it's discussed by Harold Vaughn in his highly regarded book Rifle Accuracy Facts, published, I believe, in 1997. As a professional ballistician and supervisor of the Aeroballistics Division of the Sandia National Laboratories in Albuquerque from 1959 to 1986, Vaughn certainly had the qualifications to back up what he wrote about.
Vaughn's work corroborates and informs the study of .22LR match ammo ballistics done by Larry "Landy" Landercasper, a well respected amateur ballistician who posts on Rimfire Accuracy and other forums under the name HuskerP7M8. As Landy puts it "there is no doubt whatsoever imbalanced bullets are a major source of dispersion as per Harold Vaughn's "Rifle Accuracy Facts". Dispersion is what is seen as bullets spread out in different directions from the POA and form groups that are of varying size. In other words, the greater the dispersion, the larger the group.
Landy, who has his own testing tunnel with a sophisticated chronographing system, reminds us that the two main causes of dispersion with .22LR are MV variation and bullet Cg variation. The two combined help explain why some ammos with the same MV variation produce different dispersion patterns.
The thing to remember is that unlike jacketed centerfire bullets, .22LR lead bullets are very difficult to manufacture without center of gravity issues. This means that bullet center of gravity will vary between lots, indeed can vary between bullets within a lot. Cg variation explains why some lots of the same kind of ammo do better than other lots of the same ammo, especially as distance increases. And since each rifle can contribute to Cg variation by means of its unique obturation of the bullet as it goes from chamber/leade to muzzle, different rifles shoot the same ammos with different rates of dispersion.
For the average shooter it's impossible measure a .22LR bullet center of gravity. We can only see the effects downrange. It's also impossible to know the MV until the round is shot. Excluding the influence of wind, MV and Cg variation combine together to explain dispersion rates. When a bullet has an unexpected center of gravity variation, the result will be an unexpected POI.