This should be more of a question about which gun do you like? Levers or bolts? The 375 has killed a bear for me and I would not hesitate to take a short bbl'd one like the new ruger into bear country. My preference is a 416 and oh look now I can get one of those too. I have used a 45/70 with 405 hand loads to shoot elk and it was terrible. I would not use Rem 405's on anything but paper and squirrels. My wife used a barnes 300gr X on a mule buck and it worked as good as an '06 would. I sold the gun as it was no great improvement over everything else I own. I am getting a 444 to try, so maybe I might try a 45/70 again someday. I would stick with the 375 as you have one and know what it does.