Alaskan
Not to derail this thread or anything, but I took my .416 Ruger Alaskan out to Sibbald Flats today, and put a few 400-grain handloads downrange. A 90-degree hit on 1/4" of T100 steel plate from 50 yards left a smooth, copper-ringed crater and a sizeable nipple poking out the back. Clipping the edge of the plate took out a big, cookie-sized bite.
I bought this thing to stick in the back of my float plane when I travel over grizzly country, and of course I've never fired it in anger. With open sights at 50 yards & repeatable 6" / 50 yard off-hand accuracy, I think it's enough to stop a charging grizz on the first shot.
I have a Remington 700 in .375H&H and I never felt as secure. The Alaskan is a far superior gun for this purpose, so I'm glad I have the Ruger, even as I pray I will never use it for its intended purpose. I am sure a .375 Ruger would be no less of a tool; I just wanted the extra 100 grains lobbing downrange. My suggestion - shoot both calibres before you buy; the .416 is not all that much bigger a kicker than the .375.