Quickload is your friend as well as the basic observations of pressure on case and primer.
I built a 22.250 to try and break these bullets. 7 twist, over 3100fps, 1/3 min at 200yds and never lost a bullet. McGowen prefit in a Savage. Gave up after 100rds

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For info on the 22BR, contact SteveB on this board. He has been shooting this combo for a few years in F O and knows more about it then I do. I am pretty sure his set up would handle all the bullets you want. he wasn't going that much faster then the 223's now.
With the performance I am getting from my 223 and the greatly reduced cost of set up and shooting, you may want to keep the 223 in mind.
My 22-250 used up 40gr of powder which is almost double what I shoot in my 223 for 300fps and 1/3 the barrel life.
1000yds performance is excellent too. I am really liking this combo
Jerry