Not at all, just much tougher animals. The ribs on buffalo are overlapping, and up to a couple inches thick, basically an armour plate. It acts just like a small tree in front of your shot; the bullet may not punch through those ribs and go where you planned it to in the vitals, being deflected off to another less critical place in the animal. The ungulates there also have a lot more time on the oxygen in their system, and a double lung hit doesn't do what it does at home. Plus, the buffalo has a far tougher nervous system than anything we're used to over here, due to years of evolution surviving attacks by predators, REAL predators, and rebounding from the damage. There's a good video on youtube, called "Battle at Kruger", that shows just how tough a Cape Buffalo is. A Cape Buffalo calf, quite young, gets hauled down and dragged away by a pride of lions beside a river. The lions knaw and maul the crap out of this calf, get chased down by the buffalo herd, and in ensuing minutes the lions and calf get edged closer and closer to the water. Then, a massive Nile crocodile lunges out and seizes the calf, and a pride of lions and a nile crocodile play tug of war with the calf for a good while. Ultimately, the croc lets go, and the herd fights the lion pride away, and the calf GETS UP and walks back to the herd!
The other issue is, you're typically where the buffalo best like to be, in thick bush and thorns, called jess. The stuff is brutal for deflecting shots, especially if a buffalo starts running through it and you're forced to shoot at it. A lot of North American hunters get the wrong idea about African hunting, including myself before I went over. I thought it was hype, over-excitement, sure they're bigger but they're just ungulates etc etc... now I understand. Those animals are FAR tough than what we have, and a lot less afraid of you. The shooting's closer, faster, and harder. Mag capacity means something real over there, and it's not because of poor shooting. The vitals on African game, even despite nastier bone arrangements like overlapping ribs, are much harder to get at, being higher and more behind the mass of muscle and bone in the shoulder than we're used to. Those bones are much bigger, and heavier too, and the hide an inch thick of pure leather.
Here's Giraffe hide, no fat in the if you heat it up, it just gets tougher. Cape Buffalo skin's even heavier, and messes up even good bullets on entry. My first 300gr TSX into the buffalo actually broke up, lost all four petals, keeping just a short shank of core, first time I've seen a TSX come apart like that.
Here's an Impala I heart shot, maybe a 130lb animal, or a hair more, small. Note the higher and more forward behind the mass of the shoulder location of the heart compared to NA game. Hit it through the heart with a 270gr TSX out of my .375 H&H, completely destroying the heart, and blowing the opposite leg/shoulder into a flapping appendage. A 130lb animal, that just took a 270gr TSX through the heart, STILL ran into the jess with no blood pressure, and three legs, after a springing leap at the shot. I actually was wondering if I'd missed, but a second later could see the blood on the ground from the rise I was on a hundred yards back. There's a will to live over there that will perplex North American hunters, I guarantee it... This is to say nothing of the Wildebeest I double lunged with through and through 270gr SP, sprinted and kept going like nothing happened, and kept going, and going...